15.1.1.1.1.3. cobra.core.gene
¶
15.1.1.1.1.3.1. Module Contents¶
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cobra.core.gene.
ast2str
(expr, level=0, names=None)[source]¶ convert compiled ast to gene_reaction_rule str
Parameters: - expr (str) – string for a gene reaction rule, e.g “a and b”
- level (int) – internal use only
- names (dict) – Dict where each element id a gene identifier and the value is the gene name. Use this to get a rule str which uses names instead. This should be done for display purposes only. All gene_reaction_rule strings which are computed with should use the id.
Returns: The gene reaction rule
Return type: string
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cobra.core.gene.
eval_gpr
(expr, knockouts)[source]¶ evaluate compiled ast of gene_reaction_rule with knockouts
Parameters: Returns: True if the gene reaction rule is true with the given knockouts otherwise false
Return type:
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class
cobra.core.gene.
GPRCleaner
[source]¶ Parses compiled ast of a gene_reaction_rule and identifies genes
Parts of the tree are rewritten to allow periods in gene ID’s and bitwise boolean operations
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cobra.core.gene.
parse_gpr
(str_expr)[source]¶ parse gpr into AST
Parameters: str_expr (string) – string with the gene reaction rule to parse Returns: elements ast_tree and gene_ids as a set Return type: tuple
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class
cobra.core.gene.
Gene
(id=None, name="", functional=True)[source]¶ A Gene in a cobra model
Parameters: - id (string) – The identifier to associate the gene with
- name (string) – A longer human readable name for the gene
- functional (bool) – Indicates whether the gene is functional. If it is not functional then it cannot be used in an enzyme complex nor can its products be used.
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functional
()¶ A flag indicating if the gene is functional.
Changing the flag is reverted upon exit if executed within the model as context.
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functional
(value)
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knock_out
()[source]¶ Knockout gene by marking it as non-functional and setting all associated reactions bounds to zero.
The change is reverted upon exit if executed within the model as context.
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remove_from_model
(model=None, make_dependent_reactions_nonfunctional=True)[source]¶ Removes the association
Parameters: - model (cobra model) – The model to remove the gene from
- make_dependent_reactions_nonfunctional (bool) – If True then replace the gene with ‘False’ in the gene association, else replace the gene with ‘True’
Deprecated since version 0.4: Use cobra.manipulation.delete_model_genes to simulate knockouts and cobra.manipulation.remove_genes to remove genes from the model.