3. Reading and Writing Models¶
Cobrapy supports reading and writing models in SBML (with and without FBC), JSON, YAML, MAT, and pickle formats. Generally, SBML with FBC version 2 is the preferred format for general use. The JSON format may be more useful for cobrapy-specific functionality.
The package also ships with test models in various formats for testing purposes.
import cobra.test import os from os.path import join data_dir = cobra.test.data_dir print("mini test files: ") print(", ".join(i for i in os.listdir(data_dir) if i.startswith("mini"))) textbook_model = cobra.test.create_test_model("textbook") ecoli_model = cobra.test.create_test_model("ecoli") salmonella_model = cobra.test.create_test_model("salmonella")
mini test files: mini_fbc2.xml.gz, mini_fbc1.xml, mini_fbc2.xml.bz2, mini_fbc2.xml, mini.pickle, mini.yml, mini.mat, mini.json, mini_cobra.xml
Cobrapy has native support for reading and writing SBML with FBCv2. Please note that all id’s in the model must conform to the SBML SID requirements in order to generate a valid SBML file.
<Model mini_textbook at 0x7fa99860a128>
There are other dialects of SBML prior to FBC 2 which have previously been use to encode COBRA models. The primary ones is the “COBRA” dialect which used the “notes” fields in SBML files.
Cobrapy can use libsbml, which must be installed separately (see installation instructions) to read and write these files. When reading in a model, it will automatically detect whether FBC was used or not. When writing a model, the use_fbc_package flag can be used can be used to write files in this legacy “cobra” format.
Consider having the lxml package installed as it can speed up parsing considerably.
<Model mini_textbook at 0x7fa9b74bf9b0>
cobra.io.write_sbml_model( textbook_model, "test_cobra.xml", use_fbc_package=False)
<Model mini_textbook at 0x7fa9b7f82240>
Cobrapy models have a YAML (YAML Ain’t Markup Language) representation. This format was created for more human readable model representations and automatic diffs between models.
<Model mini_textbook at 0x7fa9b7ed2860>
Often, models may be imported and exported solely for the purposes of working with the same models in cobrapy and the MATLAB cobra toolbox. MATLAB has its own ”.mat” format for storing variables. Reading and writing to these mat files from python requires scipy.
A mat file can contain multiple MATLAB variables. Therefore, the variable name of the model in the MATLAB file can be passed into the reading function:
cobra.io.load_matlab_model( join(data_dir, "mini.mat"), variable_name="mini_textbook")
<Model mini_textbook at 0x7fa999136160>
If the mat file contains only a single model, cobra can figure out which variable to read from, and the variable_name parameter is unnecessary.
<Model mini_textbook at 0x7fa9b7eda9e8>
Saving models to mat files is also relatively straightforward